Researchers have identified a pathway that triggers an immune response in cells with defective DNA repair. In particular, the ...

The Fanconi anaemia pathway is a multi-component DNA damage response system devoted to the recognition and repair of DNA interstrand crosslinks (ICLs) that impede replication and transcription.

The APOE2 gene variant protects against Alzheimer's by enhancing DNA repair and preventing neuronal senescence.

New research reveals that triggering a cell’s DNA damage response could be a promising avenue for developing novel treatments against several rare but devastating viruses for which no antiviral ...

Researchers have identified HELQ as a key regulator of DNA replication stress responses, explaining why cells lacking the ...

Scientists at Children's Medical Research Institute (CMRI) have solved a big mystery in cancer research—why cells die in different ways following radiotherapy. This surprising finding opens up new ...

Outcomes of nephrectomy in patients with pathologic complete response to immune checkpoint inhibitor therapy for renal cell carcinoma: A multicenter study. Sarcomatoid versus rhabdoid ...

Despite the significance of immune checkpoint inhibitors (ICIs) in solid tumor treatment, identifying ICI-sensitive populations remains a challenge. Mutations in DNA damage response (DDR) pathway ...

An important DNA modification is methylation, or the addition of a methyl group to the 5th carbon of cytosine. This forms 5-methylcytosine (5mC), typically associated with repression of gene ...