In a new study, scientists at the Max Planck Institute for Evolutionary Anthropology in Leipzig analyzed the impact of more ...

The researchers focused on Fanconi anemia, a rare inherited disorder characterized by a failure to repair specific types of ...

Cedars-Sinai researchers have created TY1, an experimental RNA-based drug that helps the body repair damaged DNA and restore injured tissue. The idea came from studying tiny molecular “messages” ...

Human cancers exhibit genomic instability and an increased mutation rate due to underlying defects in DNA repair. Cancer cells are often defective in one of six major DNA repair pathways, namely: ...

New research reveals that triggering a cell’s DNA damage response could be a promising avenue for developing novel treatments against several rare but devastating viruses for which no antiviral ...

Large-scale drug atlas uncovers new genome editing modulators and potential therapeutic strategies for DNA repair-deficient cancers ...

DNA can sustain serious injuries called double strand breaks, in which both strands of the helix snap. These breaks are among ...

Despite the significance of immune checkpoint inhibitors (ICIs) in solid tumor treatment, identifying ICI-sensitive populations remains a challenge. Mutations in DNA damage response (DDR) pathway ...

An elegant collaboration between researchers in the UK's two core-funded Medical Research Council Research Institutes, the Laboratory of Medical Sciences (LMS) in London and the Laboratory of ...