How an RNA-binding protein detects and responds to non-optimal codon usage in human cells

Human genes are written in long strings of three-letter units composed of four different nucleotides. These units—or ...

How do GLP-1 agonists affect gene expression?

GLP-1s are building a reputation as "wonder drugs." First characterized for their ability to improve insulin release and treat diabetes, the drugs were later found to promote weight loss and improve ...

AI model predicts chemical effects on gene expression, speeding drug discovery

Inside a diseased cell, the genes are in chaos. Some are receiving signals to overproduce a protein. Others are reducing ...
The Scientist

3D Genome Rewiring Alters Gene Expression in Cancer

Despite spanning about three billion base pairs, the human genome is wrapped up tight in a highly organized fashion in the nucleus. This coordinated structure, in part, enables the cell to regulate ...
Baylor College of Medicine

Study uncovers source of genetic variation influencing childhood brain tumors

Researchers still do not have a comprehensive picture of the factors that influence gene expression in human cancers. Understanding gene expression in cancer is important because it can reveal how the ...
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Two main gene discovery methods reveal complementary aspects of biology

The two main approaches for discovering disease genes reveal distinct aspects of biology, a new study shows. While both methods are widely used, the research found that they identify different genes ...

Gene expression program linked to neurotransmission in the living human brain identified

Researchers have identified a distinct and reproducible gene expression program associated with neurotransmission in the ...