DNA repair is essential for the maintenance of genomic stability and its failure can lead to human disease. Various DNA repair systems exist, such as base excision repair, nucleotide excision repair, ...

A new UCLA Health study has discovered in mouse models that genes associated with repairing mismatched DNA are critical in eliciting damages to neurons that are most vulnerable in Huntington's disease ...

Large-scale drug atlas uncovers new genome editing modulators and potential therapeutic strategies for DNA repair-deficient ...

A new discovery offers hope for Huntington’s disease. This discovery provides hope that a DNA repair process may help slow or stop disease progression. Research has identified a critical DNA repair ...

A new study reports that the locations where genes begin are particularly prone to mutations, and these genetic changes can ...

Researchers have revealed the structural mechanisms of a major DNA repair pathway in human cells. The research, published today as a Reviewed Preprint in eLife, is described by the editors as a ...

Researchers identified a new, sticky form of mitochondrial DNA damage that builds up at dramatically higher levels than in nuclear DNA. These lesions disrupt energy production and activate ...

After two decades in the making, scientists have cracked the code on a drug that can repair DNA, setting the scene for a new ...

Cedars-Sinai scientists have created a new experimental drug called TY1 that helps the body repair damaged DNA and restore ...

An international research team has identified a human protein, ANKLE1, as the first DNA-cutting enzyme (nuclease) in mammals ...

The bowhead whale’s remarkable lifespan and low cancer risk stem from a finely tuned DNA repair system driven by a unique protein, CIRBP. Scientists found that this mechanism not only preserves the ...