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新型蛋白保护性被动组织透明技术OptiMuS-prime:基于胆酸钠与尿素的 ...
本研究针对传统被动组织透明技术依赖SDS(十二烷基硫酸钠)导致组织损伤和蛋白破坏的局限性,开发了一种结合胆酸钠(SC)与尿素的新型透明方法OptiMuS-prime。该方法通过SC的小胶束特性高效去脂并保护蛋白完整性,辅以尿素打破氢键促进渗透,实现了对啮齿 ...
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