面对癌症，人体免疫系统中的T细胞无疑是冲锋陷阵的主力军。然而，随着与肿瘤抗争的持续，这些曾经锐不可当的战士会逐渐陷入一种被称为“耗竭(Exhaustion)”的状态，从而丧失杀伤肿瘤的能力。多年来，研究人员从代谢失调、表观遗传重塑等多个角度试图破解这 ...

When the body encounters infection or cancer, cytotoxic T lymphocytes attach to the affected cell and form the immune synapse ...

A collaboration between the University of Geneva and Lausanne University Hospital has shown in new detail how the body's defenses fight back against malignant cells. Those defenses involve T ...

This review explains how glucose scarcity, lipid disruption, amino acid deprivation, and toxic metabolites weaken CAR-T cells ...

The body’s “killer” T cells don’t just attack—they strike with astonishing precision, forming a tiny, highly organized ...

Cytotoxic T lymphocytes are the body's specialized "killer" cells, precisely eliminating infected or cancerous cells. Their ...

Despite improvements in therapies, multiple myeloma (MM) is a disease that will always relapse. Why is this? What is the key to finding effective therapies to cure MM? Evan Newell, a Professor in the ...

T cells are crucial components of our immune system, serving as critical protectors against infection and disease. But there ...

Diets and healthy eating habits hold promise for preventing and treating diseases, but far less is known about acute effects ...

By deploying a "tag and sort" fix using E3 ligases, scientists successfully cleared the protein buildup and restored T-cell ...