Efb-C通过增强FHR2与C3b的相互作用抑制补体下游反应，但不影响C3转换酶形成。研究显示Efb-C与C3b结合后，FHR2的2-4结构域与C3d的结合能力显著提升，且这种效应在完整FHR2而非截短片段中体现。尽管Efb-C单独可阻断C3前体酶形成，但与FHR2协同能更有效抑制补体C5激活后 ...
The figure focuses on complement activation by means of the alternative pathway because it is the one responsible for hemolysis in PNH. The lightning bolt symbolizes the spontaneous hydrolytic ...
C3 glomerulopathy and membranoproliferative glomerulonephritis represent a continuum of rare kidney diseases rooted in dysregulation of the alternative complement pathway. C3 glomerulopathy is ...
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