本研究通过整合29项观察性研究的荟萃分析和孟德尔随机化(MR)方法，首次系统证实内皮功能障碍蛋白vWF和E-selectin分别与心源性栓塞性卒中(CES)和大动脉粥样硬化性卒中(LAS)存在因果关联，为缺血性卒中(IS)亚型特异性防治策略提供了分子靶点。 缺血性卒中作为全球 ...

本研究针对减压病（DCI）肺损伤的分子机制，通过整合转录组学和蛋白质组学分析，首次揭示P-selectin通过PSGL-1受体激活中性粒细胞NOX2和PAD4，形成级联信号网络调控中性粒细胞外渗和NETosis。创新性构建人肺器官芯片模型动态模拟病理进程，证实靶向干预P-selectin ...

Multiple myeloma (MM) is characterized by the clonal expansion and metastatic spread of malignant plasma cells to multiple sites in the bone marrow (BM). Recently, we implicated the sialyltransferase ...

In a surprising discovery, a ‘sticky molecule’ that occurs naturally in our blood vessels could be both a culprit behind blood clots and organ failure during COVID and long COVID and the key to new ...

Dynamics of growth of transplantable sarcoma 45 (S45) in injection of autologous and allogenic serum. Dynamics of IGF-I, IGF-II and TGF-β1 in lung and liver in the early stages of metastasis in ...

Selectins are required for the trafficking of innate immune system cells, T lymphocytes and platelets. The absence of selectins or their ligands has severe health ...

In a surprising discovery, a "sticky molecule" that occurs naturally in our blood vessels could be both a culprit behind blood clots and organ failure during COVID and long COVID and the key to new ...