Background Most patients with biliary tract cancer (BTC) do not derive durable clinical benefit (DCB) from immune checkpoint inhibitors (ICIs), underscoring the urgent need for predictive biomarkers.

Abstract: Single-cell RNA sequencing (scRNA-seq) has profoundly reshaped our understanding of cellular diversity and functionality; however, accurate cell-type annotation is required for biological ...

The authors established a useful syndetome differentiation protocol from human induced pluripotent stem cells, guided by single-cell transcriptomic analysis. Their findings could significantly impact ...

Single-cell transcriptomics has revolutionised our understanding of the cellular complexity underlying neurodegenerative disorders by enabling the high-resolution profiling of individual brain cells.

Scientists have unveiled a detailed "atlas" of the placenta and uterus, showing how these unique tissues grow and evolve throughout pregnancy to accommodate a developing fetus. In charting this new ...

The single-cell genomics industry does not stop advancing, with a steady stream of new companies, kits, acquisitions, and more. One new company, ArgenTag, was founded in Argentina during the COVID-19 ...

This manuscript by Kaur et al. identifies differential gene expression in distinct cell populations, specifically myeloid and lymphoid cells, following short-term exposure to e-cigarette aerosols with ...

Abstract: Aging progresses unevenly across cells, making chronological age an incomplete measure of biological decline. Aging clocks, machine learning models trained on molecular features, offer a ...

How do nervous systems evolve to generate the extraordinary diversity of animal behaviors? We addressed this question by investigating how neural circuits evolve in fruit fly species with divergent ...

Background: Lung tissue exhibits intricate spatial organization and dynamic cellular interactions. However, the molecular mechanisms underlying pulmonary arterial hypertension (PAH) remain poorly ...