It’s important NOT to stop progestogen from your HRT without medical advice if you’re struggling with it. I know this isn’t what you want to hear. If you still have a uterus, progesterone (or a progestogen) is essential to protect the womb lining from the effects of oestrogen. Taking oestrogen without it can significantly increases the risk of endometrial cancer. If you don’t have a uterus, then a progestogen is usually not needed unless you had endometriosis or your cervix left behind (subtotal